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U.S. FULL PRESCRIBING INFORMATION, including Boxed WARNINGS, and Medication Guide.

Elderly people with psychosis related to dementia (for example, an inability to perform daily activities as a result of increased memory loss), treated with antipsychotic medicines including ABILIFY®(aripiprazole), are at an increased risk of death compared to placebo. ABILIFY is not approved for the treatment of people with dementia-related psychosis. See More Safety Information

INDICATION: ABILIFY (aripiprazole) is used for the treatment of manic and mixed episodes associated with bipolar I disorder in adults and in pediatric patients 10 to 17 years of age. It can be used either by itself or as an add-on treatment to lithium or valproate.

The individuals who appear on this page are for illustrative
purposes only. Any person depicted here is a model and not an
actual patient unless otherwise noted.

How ABILIFY Is Thought to Work

While the exact way that ABILIFY (aripiprazole) works is not fully understood, many scientists believe it affects the activity of some key brain chemicals (for example, dopamine and serotonin). To learn more about the brain,
bipolar I disorder, and ABILIFY, choose a topic below.

Brain Chemistry

Brain Chemistry
Brain Chemistry

The brain is made up of billions of nerve cells. These cells carry a constant stream of information.

When the information reaches the end of a nerve cell, the cell releases chemical neurotransmitters that carry the information from one nerve cell to the next. This is how information moves through the entire nervous system.

Bipolar I Disorder

Bipolar I Disorder
Bipolar I Disorder

There are many different chemical neurotransmitters needed for brain function. Dopamine and serotonin are two chemicals that play a key role in your emotional health.

Many scientists believe that when the levels of dopamine and serotonin aren’t quite right, this may result in the symptoms of bipolar I disorder.

How ABILIFY Is Thought to Work

How ABILIFY Is Thought to Work
How ABILIFY Is Thought to Work

It is thought that ABILIFY may work by affecting the activity of some key brain chemicals—adjusting the activities of both dopamine and serotonin. Keep in mind, the exact way ABILIFY (or any other medication for bipolar I disorder) works is unknown.

Important Safety Information: ABILIFY (aripiprazole) and medicines like it have been associated with difficulty swallowing which may lead to aspiration or choking.

See More Safety Information
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  • Side Effect FAQs

    Learn about the most common side effects of ABILIFY, and how it could impact your sleep, weight, and more.