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U.S. FULL PRESCRIBING INFORMATION, including Boxed WARNINGS, and Medication Guide.

Elderly people with psychosis related to dementia (for example, an inability to perform daily activities as a result of increased memory loss), treated with antipsychotic medicines including ABILIFY®(aripiprazole), are at an increased risk of death compared to placebo. ABILIFY is not approved for the treatment of people with dementia-related psychosis. See More Safety Information

INDICATION: ABILIFY (aripiprazole) is used for the treatment of manic and mixed episodes associated with bipolar I disorder in adults and in pediatric patients 10 to 17 years of age. It can be used either by itself or as an add-on treatment to lithium or valproate.

The individuals who appear on this page are for illustrative
purposes only. Any person depicted here is a model and not an
actual patient unless otherwise noted.

Symptoms of Bipolar I Disorder

People with bipolar I disorder experience extreme mood swings that can take 3 different forms: manic, depressive, and mixed episodes. Symptoms can include both a lowering of mood (depression) and an exaggerated elevation of mood (mania).

Manic Episodes

Manic Episodes<

In a manic episode, some people with bipolar I disorder may experience an elevated (extremely happy) mood. Others may feel very agitated and act uncooperatively and aggressively.

A diagnosis for a manic episode includes an elevated or an irritable mood lasting at least a week, plus 3 or more of the following symptoms:

  • An inflated feeling of power, greatness, or importance
  • Needing little sleep
  • Talking more than usual
  • Racing thoughts
  • Being easily distracted (attention shifts between many topics in just a few minutes)
  • Intense focus on goal-directed activity or restlessness
  • Risky or impulsive behavior (like excessive spending sprees)

Mixed Episodes

Manic Episodes<

During a mixed episode, people have symptoms of both manic and depressive episodes that last at least a week. For example, a person may feel very sad or hopeless while also feeling extremely energized. In addition, they are often agitated, have trouble sleeping, experience major changes in appetite, experience delusions or hallucinations, and have suicidal thoughts.

A diagnosis for a major depressive episode requires having a depressed mood or loss of interest or pleasure in activities a person used to enjoy. In addition, 4 of the following symptoms must also be present nearly every day for at least 2 weeks and be troublesome enough to interfere with daily functioning:

  • Low energy or fatigue
  • Difficulty concentrating
  • Irritability, restlessness, or being slowed down
  • Feeling worthless or guilty
  • Trouble sleeping or sleeping too much
  • Significant weight change
  • Thoughts about suicide or dying

Find out information about pediatric patients with bipolar I disorder 10 to 17 years of age.

Important Safety Information: High fever, stiff muscles, confusion, sweating, changes in pulse, heart rate and blood pressure may be signs of a condition called neuroleptic malignant syndrome (NMS), a rare and serious condition that can lead to death.

See More Safety Information
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