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U.S. FULL PRESCRIBING INFORMATION, including Boxed WARNINGS, and Medication Guide.

Elderly people with psychosis related to dementia (for example, an inability to perform daily activities as a result of increased memory loss), treated with antipsychotic medicines including ABILIFY®(aripiprazole), are at an increased risk of death compared to placebo. ABILIFY is not approved for the treatment of people with dementia-related psychosis. See More Safety Information

INDICATION: ABILIFY (aripiprazole) is indicated for the treatment of schizophrenia in adults and adolescents 13 to 17 years of age.

How ABILIFY Is Thought to Work

While the exact way ABILIFY (aripiprazole) works is not fully understood, many scientists believe it affects
the activity of some key brain chemicals (for example, dopamine and serotonin). To learn about the brain, schizophrenia, and ABILIFY, choose a topic below.

Brain Chemistry

Brain Chemistry

The brain is made up of billions of nerve cells. These cells carry a constant stream of information.

When the information reaches the end of a nerve cell, the cell releases chemical neurotransmitters that carry the information from one nerve cell to the next. This is how information moves through the entire nervous system.



There are many different chemical neurotransmitters needed for brain function. Dopamine and serotonin are two chemicals that play a key role in mood and emotion.

Many scientists believe that when the levels of dopamine and serotonin are either too high or too low, this may result in the symptoms of schizophrenia.

How ABILIFY Is Thought to Work

How ABILIFY Is Thought to Work

It is thought that ABILIFY may work by affecting the activity of some brain chemicals—adjusting the activities of both dopamine and serotonin. Keep in mind, the exact way ABILIFY (or any
other medicine for schizophrenia)
works is unknown.

Important Safety Information: Uncontrollable movements of face, tongue, or other parts of body may be signs of a serious condition called tardive dyskinesia (TD). TD may not go away, even if you stop taking ABILIFY (aripiprazole). TD may also start after you stop taking ABILIFY (aripiprazole).

See More Safety Information
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  • ABILIFY and Your Treatment Plan

    If you and your doctor are considering ABILIFY, or if you have already started taking it, you may want to discuss ways to follow your treatment plan.